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Metabolic Profiling at COVID-19 Onset Shows Disease Severity and Sex-Specific Dysregulation FRONTIERS IN IMMUNOLOGY.
3 Ceballos, Francisco C.; Virseda-Berdices, Ana; Resino, Salvador; et al; Jimenez-Sousa, Maria Angeles. (19/19). 2022. Metabolic Profiling at COVID-19 Onset Shows Disease Severity and Sex-Specific Dysregulation FRONTIERS IN IMMUNOLOGY. ISSN 1664-3224.
Metabolomic changes after DAAs therapy are related to the improvement of cirrhosis and inflammation in HIV/HCV-coinfected patients.
4 Virseda-Berdices, Ana; Rojo, David; Martinez, Isidoro; et al; Jimenez-Sousa, Maria Angeles. (14/14). 2022. Metabolomic changes after DAAs therapy are related to the improvement of cirrhosis and inflammation in HIV/HCV-coinfected patients. BIOMEDICINE & PHARMACOTHERAPY. 147:112623. ISSN 1950-6007.
HCV Cure With Direct-Acting Antivirals Improves Liver and Immunological Markers in HIV/HCV-Coinfected Patients FRONTIERS IN IMMUNOLOGY.
7 Brochado-Kith, Oscar; Martinez, Isidoro; Berenguer, Juan; et al; Jiménez-Sousa, Maria Angeles (‡, AC); Resino, Salvador (‡, AC). (13/13). 2021. HCV Cure With Direct-Acting Antivirals Improves Liver and Immunological Markers in HIV/HCV-Coinfected Patients FRONTIERS IN IMMUNOLOGY. 12:723196. ISSN 1664-3224.
Plasma miRNA profile at COVID-19 onset predicts severity status and mortality
3. Fernández-Pato A; Virseda-Berdices A; Resino S; et al; Fernández-Rodríguez A (AC). (20/20). 2022. Plasma miRNA profile at COVID-19 onset predicts severity status and mortality Emerging Microbes and Infections. Taylor & Francis Online. ISSN 2222-1751.
DOIAdditional Information
The research activity of the Viral Biology group since its beginnings in the 1980s has focused on respiratory viruses, especially on the study of the mechanisms of virus entry into the cell, evolutionary aspects, antigenic properties and vaccine development.
Currently, the group's objectives are focused on the characterisation of the immune response and the development of vaccines against human pneumoviruses: human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV).
Both viruses are considered to be important respiratory pathogens of high clinical relevance, especially in the paediatric population.
Safe and effective vaccines against these viruses are currently not available. Soluble protein subunits based on the fusion protein (F-protein) of hRSV and hMPV are being developed in the laboratory by protein engineering for use as vaccines against human pneumoviruses.
On the other hand, and thanks to the characterisation of the type of humoral response induced by the F proteins of these viruses, the laboratory is also involved in the isolation of monoclonal antibodies and nanoantibodies for use as treatments against these viruses.
The research activity of the Viral Biology group since its beginnings in the 1980s has focused on respiratory viruses, especially on the study of the mechanisms of virus entry into the cell, evolutionary aspects, antigenic properties and vaccine development.
Currently, the group's objectives are focused on the characterisation of the immune response and the development of vaccines against human pneumoviruses: human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV).
Both viruses are considered to be important respiratory pathogens of high clinical relevance, especially in the paediatric population.
Safe and effective vaccines against these viruses are currently not available. Soluble protein subunits based on the fusion protein (F-protein) of hRSV and hMPV are being developed in the laboratory by protein engineering for use as vaccines against human pneumoviruses.
On the other hand, and thanks to the characterisation of the type of humoral response induced by the F proteins of these viruses, the laboratory is also involved in the isolation of monoclonal antibodies and nanoantibodies for use as treatments against these viruses.